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Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 500 MG
Supplier: Medchemexpress LLC HY141623500MG
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.
- Inhibits human TXNIP promoter activity and reduces TXNIP mRNA and protein levels in INS-1 cells.
- Lowers glucagon secretion in TC1-6 cells and decreases glucagon secretion and action in vivo.
- Reduces glucagon-induced glucose output from primary hepatocytes and blocks hepatic glucose output in vivo.
- Reverses obesity- and Streptozotocin (STZ)-induced diabetes and hepatic steatosis in mice.
- Orally bioavailable.
- Well-tolerated in male C57BL/6J mice.
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