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Medchemexpress LLC Sri-37330 hydrochloride | 2322245-49-6 | 99.72% | C16H20ClF3N4O2S | 1 G
Supplier: Medchemexpress LLC HY1416231G
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis. This compound can be used for type 2 diabetes research.
- Inhibits human TXNIP promoter activity in INS-1 cells.
- Decreases TXNIP mRNA and protein levels in INS-1 cells.
- Blocks polymerase II binding to the E-box motif of the TXNIP promoter.
- Reduces glucagon secretion in TC1-6 cells.
- Inhibits glucagon-induced glucose output from primary hepatocytes.
- Decreases glucagon secretion and action, and blocks hepatic glucose output in vivo.
- Well tolerated in male C57BL/6J mice.
- Reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice.
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