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Medchemexpress LLC SRT 2183 | 1001908-89-9 | 98.1% | 468.57 | 5 MG
Supplier: Medchemexpress LLC HY197595MG
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. It induces growth arrest and apoptosis, accompanied by deacetylation of STAT3 and NF-κB, and a reduction in c-Myc protein levels. This product is for research use only and is not sold to patients.
- Selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM.
- Induces growth arrest and apoptosis.
- Causes deacetylation of STAT3 and NF-κB.
- Reduces c-Myc protein levels.
- Inhibits the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner.
- Induces expression of DNA-damage response genes associated with accumulation of phospho-H2A.X levels.
- Inhibits RANKL-induced osteoclast differentiation, fusion, and resorptive capacity without affecting osteoclast survival.
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