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Medchemexpress LLC Ssr180711 (hydrochloride) | 446031-79-4 | 99.9% | 361.66 | 100 MG
Supplier: Medchemexpress LLC HY19411100MG
SSR180711 hydrochloride is an orally active, selective, and reversible α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. It acts on rat α7 n-AChR (Ki=22 nM; IC50=30 nM) and human α7 n-AChR (Ki=14 nM; IC50=18 nM). This compound increases glutamatergic neurotransmission, ACh release, and long-term potentiation (LTP) in the hippocampus. It is intended for research use only.
- Orally active
- Selective and reversible α7 n-AChRs partial agonist
- Increases glutamatergic neurotransmission, ACh release, and long-term potentiation (LTP) in the hippocampus
- Selective for the α7 receptor subtype compared to α4β2, α3β2, α3β4, and α1β1γδ human n-AChR subtypes (IC50>5 μM)
- Rapidly penetrates into the brain (ID50=8 mg/kg; p.o.)
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