AdipoGen ST2 human pAb

Supplier:  AdipoGen AG25A0058C100

Polyclonal Antibody. Recognizes soluble human ST2. Detects a band of ~50kDa by Western blot and the endogenous ST2 by Flow Cytometry. Source Rabbit. Applications ELISA, FACS, WB. Liquid. In PBS containing 0.02% sodium azide. ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells ILC2, originally referred to as natural helper NH cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naïve state.

Catalog No. 50-256-3256