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Cayman Chemical Standard RT-qPCR Enzyme Maste
Supplier: Cayman Chemical 407061 EA
A Cdk12 and Cdk13 inhibitor binds to Cdk12 and Cdk13 (Kds 98 and 4.9 nM respectively) inhibits Cdk12- and Cdk13-dependent phosphorylation of RNA polymerase II in MDA-MB-231 cells (EC50 105.5 nM) inhibits the proliferation of MDA-MB-231 MDA-MB-468 Hs 578T and MDA-MB-436 breast cancer cells (EC50s 15.5 22.1 19.9 and 24.9 nM respectively) induces the DNA damage response and apoptosis in MDA-MB-231 from 30-90 nM reduces tumor volume and decreases the number of mice with tumors greater than 1000 mm3 in a PDX model of breast cancer at 20 mg/kg
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