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STEMCELL Technologies STAT5 Inhibitor, Size: 5 mg
Supplier: STEMCELL Technologies 73852
STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that specifically suppresses STAT5 (IC₅₀ = 47 µM) via binding to its SH2 domain. It shows reduced potency towards the SH2 domains of STAT1, STAT3, or LCK (Müller et al.).IMMUNOLOGY· Induces partial apoptosis of mature eosinophils at high concentrations (Schwartz et al.).· Rescues IL-17 production in a proportion of restimulated TH17 clones (Zielinski et al.)· Reduces growth of induced regulatory T cells (iTregs) in vitro (Betts et al.).
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WARNING: Cancer - www.P65Warnings.ca.gov
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