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Reprocell Stemolecule LDN-193189, 10 mg, yellow powder
Supplier: Reprocell 04007410
Stemolecule LDN-193189 (10 mg) from REPROCELL is a cell-permeable small molecule designed to inhibit BMP type I receptors, particularly ALK2 and ALK3. This hydrochloride salt enhances solubility in DMSO, making it a viable alternative to a previous formulation. Modulating BMP signaling pathways, this compound effectively inhibits phosphorylation of key proteins involved in developmental processes, and it demonstrates high selectivity against other receptors. Its applications include research on reducing abnormal bone growth in specific medical models.
- Cell-permeable small molecule
- Potent inhibitor of BMP type I receptors ALK2 and ALK3
- Improved solubility in DMSO
- Inhibits Smad1, Smad5, and Smad8 phosphorylation
- High selectivity, weakly inhibits ALK4, ALK5, and ALK7
- Purity greater than 96% by HPLC
- Formulated as a yellow powder
- Shipping requires cool pack conditions
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