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Reprocell STEMOLECULE WNT INHB IWP-4 2MG
Supplier: Reprocell 040036
Stemolecule Wnt Inhibitor IWP-4, 2mg. Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt / b-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and b-catenin1. Chemical name: 2-(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 686772-17-8.
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