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Reprocell Stemolecule Y27632, 10 mg, cell-permeable small molecule, reversible ATP-competitive ROCK inhibitor, white solid, inhibits ROCK1 (220 nM), ROCK2 (300 nM), >97% purity
Supplier: Reprocell 04001210
Stemolecule Y27632 is a cell-permeable small molecule that serves as a highly potent and selective inhibitor of Rho-associated kinase (ROCK), specifically targeting ROCK1 and ROCK2. This compound is extensively utilized in stem cell research to enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without compromising their self-renewal properties and pluripotency. Additionally, it improves the survival of ES cell-derived neural precursors during transplantation and significantly enhances cell recovery after cryopreservation when combined with Pifithrin-u.
- Molecular target: Rho-associated kinase (ROCK)
- Mechanism of action: Reversible ATP-competitive inhibitor
- Inhibitory concentration (Ki): ROCK1 220 nM, ROCK2 300 nM
- Purity: >97% by HPLC
- Formulation: White solid
- Solubility: Reconstitute in DMSO
- Pack size: 10 mg
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