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Medchemexpress LLC STF-31 | 724741-75-7 | 99.8% | 423.53 | 5 MG
Supplier: Medchemexpress LLC HY187285MG
STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. It is also a NAMPT inhibitor and inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells.
- Selective inhibitor of glucose transporter 1 (GLUT1).
- NAMPT inhibitor.
- Inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells.
- Specifically toxic to RCC4 cells at concentrations of 0.01-10 μM, while RCC4/VHL cells are relatively unaffected.
- Causes necrotic cell death and does not induce autophagy, apoptosis, or DNA damage at concentrations of 1.25-5 μM for 3 days.
- Reduces light-induced CX3CR1gfp/+ mice microglial activation and retinal degeneration in vivo at 10 mg/kg.
- Promotes accumulation of necrotic thymocytes after Dexamethasone-induced apoptosis in vivo at 10 mg/kg.
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