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Apexbio Technology LLC STF-62247 315702-99-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B21515.1
STF-62247 (CAS 315702-99-9) is a small molecule that selectively targets renal cell carcinoma (RCC) cells carrying von Hippel-Lindau (VHL) gene deletions It exhibits cytotoxicity in both wild-type and VHL-deficient RCC cells via a mechanism independent of hypoxia-inducible factor (HIF) with reported IC50 values of 16 M and 0 625 M respectively In VHL-deficient RCC cells STF-62247 induces acidification autophagy and subsequent apoptotic cell death In mouse xenograft models bearing VHL-deficient SN12C tumors STF-62247 significantly reduced tumor growth This compound is useful for studying therapeutic strategies targeting VHL-deficient tumors
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