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Cayman Chemical Stndard DIluent asy Reagen 4mL
Supplier: Cayman Chemical 7007324 ML
A multi-kinase inhibitor inhibits FLT3 CSF1R c-Kit FGFR1 FGFR3 VEGFR1 -2 and -3 PDFGRa and PDGFRB (IC50s 1 36 2 8 9 10 13 8 27 and 210 nM respectively) inhibits the proliferation of human multiple myeloma cell lines expressing mutant but not wild-type FGFR3 (IC50s 90-550 and >2500 nM respectively) decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells at 500 nM inhibits bFGF-induced angiogenesis in a Matrigel™ plUG assay in mice at 3-300 mg/kg for 8 days reduces tumor growth in KM12L4A DU145 and MV4-11 mouse xenograft models (ED50s 17 23 and 3 mg/kg per day respectively)
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