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Cayman Chemical STING Agonist 12L, Purity: ≥98%, CAS: 2913152-30-2, 5 mg
SDP

Catalog No. 502916720
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A STING agonist; binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232H, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively); induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM, respectively); induces IFNB1, CXCL10, and IL6 mRNA expression in THP-1 cells at 5 µM; increases plasma IFN-β levels and reduces tumor volume and the number of lung metastases in a B16/F10 murine melanoma model at 10 mg/kg

Catalog No. 50-291-6720 Supplier Cayman Chemical Supplier No. 383445 MG
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A STING agonist; binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232H, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively); induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM, respectively); induces IFNB1, CXCL10, and IL6 mRNA expression in THP-1 cells at 5 µM; increases plasma IFN-β levels and reduces tumor volume and the number of lung metastases in a B16/F10 murine melanoma model at 10 mg/kg

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