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Cayman Chemical STng PROTAC SP23 1mg
Supplier: Cayman Chemical 392741 MG
A PROTAC that drives STING degradation; degrades STING in THP-1 cells (DC50 = 3.2 µM); decreases cGAMP-induced increases in the levels of IFN-β, IL-6, and CXCL10 in THP-1 cells at 2.5-10 µM; reduces kidney weight, improves kidney function, and increases the survival rate in a mouse model of cisplatin-induced acute kidney injury at 30 and 60 mg/kg
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