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Medchemexpress LLC STO-609 | 52029-86-4 | 98.20% | 314.29 | 5 MG
Supplier: Medchemexpress LLC HYP18055MG
STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK). It inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.
- Inhibits activities of recombinant CaM-KKα and CaM-KKβ isoforms with Ki values of 80 and 15 ng/mL, respectively.
- Inhibits their autophosphorylation activities.
- Highly selective for CaM-KK without significant effect on downstream CaM kinases (CaM-KI and -IV).
- Inhibits constitutively active CaM-KKα as well as the wild-type enzyme.
- Suppresses Ca2+-induced activation of CaM-KIV in transfected HeLa cells in a dose-dependent manner.
- Reduces endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells at 1μg/mL (80% inhibitory rate).
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