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Medchemexpress LLC Sto-609 | 52029-86-4 | 98.20% | 314.29 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1980550MG

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STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK). It inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 of approximately 0.02 g/ml. It is highly selective for CaM-KK without significant effect on downstream CaM kinases.

  • Inhibits recombinant CaM-KKα and CaM-KKβ isoforms and their autophosphorylation activities.
  • Has an IC50 value against CaM-KII of 10 μg/mL.
  • Inhibits constitutively active CaM-KKα and wild-type enzyme.
  • Suppresses Ca2+-induced activation of CaM-KIV in a dose-dependent manner in transfected HeLa cells.
  • Reduces endogenous activity of CaM-KK in SH-SY5Y neuroblastoma cells at 1μg/mL (80% inhibitory rate).

Catalog No. 50-004-02066


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