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Apexbio Technology LLC Streptozocin 18883-66-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A44575.1
Streptozocin is an antibiotic derivative commonly utilized as an antitumor agent in biomedical research It exerts its biological function primarily through DNA alkylation resulting in targeted cellular toxicity Notably streptozocin selectively acts on pancreatic -cells by depleting intracellular nicotinamide adenine dinucleotide (NAD ) leading to dysregulated glucose metabolism and experimental induction of diabetes mellitus In addition streptozocin is frequently employed in vitro and in vivo to establish diabetic animal models for examination of diabetes-related complications and screening antidiabetic therapies Reported IC50 values vary depending on cell types and conditions with typical values ranging approximately from 11 to 25 M in pancreatic -cell lines
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