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Medchemexpress LLC Streptozotocin | 18883-66-4 | MFCD00006709 | ≥98% | 265.22 | 5 G
Supplier: Medchemexpress LLC HY137535G
Streptozotocin (STZ) is an antibiotic commonly used in experimental animal models to induce diabetes. It enters B cells via the glucose transporter (GLUT2) and causes DNA alkylation, leading to the apoptosis of β cells. This compound is suitable for constructing models of both type 1 and type 2 diabetes.
- Induces cytotoxicity, oxidative stress, and mitochondrial dysfunction in HepG2 cells.
- Specifically transported by GLUT2 in GLUT2-expressing cells.
- Highly water-soluble and often dissolved in cold acidic citric acid buffer (pH 4.0-4.7).
- Distributes widely throughout the body, including crossing the blood-brain barrier and placenta.
- Undergoes chemical modification in the liver, converting into an active form that causes DNA methylation and damages pancreatic β-cells.
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