Cayman Chemical Strogen receptr F regIon 100uL

Supplier:  Cayman Chemical 32770100 UL

A 5-HT1A agonist (IC50 4.3 nM in a radioligand binding assay) selective for 5-HT1A over 5-HT2 and a1-adrenergic receptors (IC50s 697 and 630 nM respectively) as well as a panel of 13 additional neurotransmitter receptors and ion channels (IC50s ≥10 UM for all) but also binds σ receptors (IC50 73 nM) increases NGF-induced neurite outgrowth and a-actinin levels in PC12 cells at 250 nM decreases hippocampal neuronal damage and reduces impairments in sensorimotor function in rat models of transient global ischemia induced by 4-VO and sciatic nerve crush injury respectively at 10 mg/kg per day inhibits CNS mononuclear cell infiltration and increases in cerebrospinal fluid IgG levels in a rat model of EAE induced by myelin basic protein at 10 mg/kg per day

Catalog No. 50-294-6877