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Selleck Chemical LLC STX-478-E1815-100MG
Supplier: Selleck Chemical LLC E1815100MG
STX-478 is a highly potent mutant-selective allosteric inhibitor of PI3K that selectively targets prevalent mutant forms of PI3K It demonstrates strong efficacy against common PI3K helical- and kinase-domain mutations including the H1047R variant with an IC50 value of 9 4 nmol/L STX-478 exhibits 14-fold greater selectivity for mutant PI3K over the wild-type form It spares metabolic dysfunction and improves therapeutic response in PI3K -Mutant Xenografts
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