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Apexbio Technology LLC SU 5402 215543-92-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A38435.1
SU 5402 (CAS 215543-92-3) is a selective receptor tyrosine kinase inhibitor targeting VEGFR2 FGFR1 and PDGFR with respective IC50 values of 0 02 M 0 03 M and 0 51 M It exhibits minimal inhibitory activity against EGFR ( 100 M IC50) SU 5402 inhibits FGFR-mediated phosphorylation events impacting downstream signaling pathways including ERK1/2 STAT3 and MAP kinases leading to cell cycle arrest and induction of apoptosis particularly in FGFR3-dependent multiple myeloma cell lines This compound serves as a relevant tool for exploring receptor tyrosine kinase signaling in cancer research
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