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Apexbio Technology LLC SU 9516 377090-84-1 50mg
Supplier: Apexbio Technology LLC A446750
SU 9516 (CAS 377090-84-1) is a potent and selective inhibitor of cyclin-dependent kinase 2 (CDK2) with an IC50 of 22 nM It exhibits markedly reduced activity against CDK1 CDK4 PKC p38 and PDGFR SU 9516 disrupts cell cycle progression by inhibiting CDK2-mediated phosphorylation of the retinoblastoma protein (pRb) and induces cell cycle arrest and apoptosis in various cancer cell lines including colon carcinoma and leukemia It has been shown to reduce levels of Cyclin D1 and CDK2 promote mitochondrial translocation of Bax cytochrome c release and activate caspase cascades SU 9516 serves as a valuable chemical probe for investigating CDK2 function and cell cycle regulation in cancer research
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