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Apexbio Technology LLC SU6656 330161-87-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B58395.1
SU6656 (CAS 330161-87-0) is a selective small-molecule inhibitor targeting Src family tyrosine kinases enzymes involved in pathways promoting cellular survival proliferation angiogenesis and invasion In NIH 3T3 cells SU6656 suppresses PDGF- and Src-induced cell cycle progression and c-Myc expression In UT-7/TPO leukemia cells SU6656 induces cell cycle arrest with increased DNA content and elevates CD41/CD61 surface expression Additionally SU6656 enhances radiation-mediated endothelial apoptosis and vascular disruption by inhibiting Src-dependent Akt phosphorylation suggesting its potential utility in antitumor angiogenesis research
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