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Medchemexpress LLC Succinyl-Coenzyme A sodium | 108347-97-3 | ≥99.0% | 1 MG
Supplier: Medchemexpress LLC HY1378081MG
Succinyl-Coenzyme A sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. It is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl-Coenzyme A sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Insufficiency of Succinyl-Coenzyme A sodium caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation, and neurological abnormalities.
- It can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis).
- It acts as a substrate for rat liver δ-aminolevulinic acid synthase-1 with a Michaelis constant (Km) of 6-120 μmol/L.
- It does not bind to recombinant NLRX1 in an in vitro pull-down assay.
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