Apexbio Technology LLC Sulfamethazine 57-68-1 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B21325.1

Sulfamethazine (Sulfadimidine) is a sulfonamide antimicrobial agent that exerts antibacterial activity by competitively inhibiting bacterial dihydropteroate synthase an enzyme crucial for the synthesis of folic acid in bacteria Through this enzyme inhibition sulfamethazine disrupts bacterial folate metabolism impairing bacterial DNA and protein synthesis pathways In biomedical research this compound is commonly employed as an investigative tool for studying bacterial infections particularly in animal models representing respiratory and gastrointestinal infections attributed to susceptible bacterial strains In vitro studies report IC50 values for bacterial dihydropteroate synthase inhibition typically ranging from 5 to 50 M depending on experimental conditions and bacterial species tested Additionally sulfamethazine serves as a reference compound in research examining antimicrobial resistance and pharmacokinetic parameters

Catalog No. 50-000-61809