Apexbio Technology LLC Sulfasalazine 599-79-1 5g

Supplier:  Apexbio Technology LLC A57705000

Sulfasalazine (599-79-1) is a small-molecule inhibitor targeting the NF- B signaling pathway and the cystine-glutamate antiporter system (system Xc-) It is designed to suppress NF- B activation and inhibit cystine uptake thereby modulating inflammatory gene expression and intracellular glutathione synthesis Sulfasalazine exerts its biological activity primarily through inhibition of NF- B activation and blockade of system Xc- In in vitro studies sulfasalazine demonstrates growth inhibition and induction of apoptosis in several cancer cell lines including MIA PaCa-2 PANC-1 and glioblastoma cells with reported IC50 values ranging from approximately 0 2 to 0 5 mM depending on cell type and conditions Based on these pharmacological properties sulfasalazine holds research potential in inflammation NF- B signaling oxidative stress modulation and cancer studies

Catalog No. 50-000-93676