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Cayman Chemical SulfIsoxazole 1g
SDP

Supplier:  Cayman Chemical 259801 G

Encompass_Preferred

An inhibitor of HDAC6 (IC50 0.0047 UM).{33843} selective for HDAC6 over HDAC1 -2 -3 and -8 (IC50s 0.058 0.048 0.051 and 0.1 UM respectively) HDAC4 -5 -7 and -9 (IC50s 7 5 1.4 and 10 UM respectively) SIRT1 and SIRT2 (IC50s 10 UM for both) and HDAC11 (IC50 10 UM) induces accumulation of acetylated a-tubulin in OCI-LY10 cells from 0.5-2.5 UM induces cytotoxicity in several multiple myeloma cell lines (IC50s 2-8 UM) decreases tumor volume and increases survival in an OCI-LY10 mouse xenograft model at a 50 mg/kg in combination with bortezomib decreases liver and kidney cyst area and liver fibrosis in PCK rats in a model of polycystic liver disease

Catalog No. 50-293-5847


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