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Apexbio Technology LLC Sulindac 38194-50-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B20445.1
Sulindac (CAS 38194-50-2) is a nonsteroidal anti-inflammatory drug that functions as a prodrug and is metabolized in vivo to pharmacologically active sulindac sulfide and sulindac sulfone Sulindac sulfide acts as a cyclooxygenase inhibitor and modulates intracellular signaling pathways including the repression of ras activity Sulindac sulfone possesses antitumor properties independent of cyclooxygenase inhibition Due to these distinct metabolites and their activities sulindac is utilized in biomedical research for studying inflammatory processes cyclooxygenase-mediated pathways and the chemopreventive mechanisms involved in tumorigenesis
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