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Cayman Chemical Sulindac Inhibitors

Supplier: Cayman Chemical 100043861 G

An NSAID, a COX-2 inhibitor (IC50 0.79 µM), and a prodrug form of sulindac sulfide selective for COX-2 over COX-1 (IC50 >1,000 µM) inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
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