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Cayman Chemical Sulindac sulfide

Supplier: Cayman Chemical 100043871 MG

An active metabolite of sulindac inhibits COX-1 and COX-2 (IC50s 1.9 and 1.21 µM, respectively) inhibits aldose reductase (IC50 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications inhibits colorectal cancer growth in vitro and in vivo
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