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AdipoGen SuperKillerTRAIL, Soluble (human) (rec.) MultiPack (3 x 20 ug)
Supplier: AdipoGen AG40T00023020
SuperKillerTRAIL, Soluble (human) (rec.) MultiPack (3 x 20 ug), Adipogen Life Sciences. Protein. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge. Source: E. coli. Endotoxin content: <0.01EU/µg purified protein (LAL test; Lonza). Liquid. In 20mM HEPES, pH 7.4, 150mM NaCl, 0.005% Tween 20, 1% sucrose, 1mM DTT. Binds to human TRAIL receptors. Purity: >98% (SDS-PAGE). TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC).
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