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Cayman Chemical SuprafenacIn 10mg
Supplier: Cayman Chemical 3115810 MG
An inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 μM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg
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