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Apexbio Technology LLC SW033291 459147-39-8 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A87095.1

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SW033291 (CAS 459147-39-8) is a small molecule inhibitor targeting the prostaglandin-degrading enzyme 15-PGDH It inhibits 15-PGDH activity non-competitively displaying potent inhibition with an IC50 of 1 5 nM and an apparent dissociation constant (Ki app) of approximately 0 1 nM Cellular assays in A549 cells demonstrate that SW033291 elevates prostaglandin E2 (PGE2) levels (EC50 75 nM) In vivo administration of SW033291 in mice significantly elevates tissue PGE2 concentrations stimulates hematopoietic cytokine expression expands hematopoietic stem and progenitor cell populations and promotes neutrophil expansion Thus SW033291 represents a research tool for studying PGE2-related pathways in tissue regeneration and hematopoiesis

Catalog No. 50-000-61676


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