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Medchemexpress LLC Synstatin (92-119) | 1259384-47-8 | 99.4% | 3032.27 | 5 MG
Supplier: Medchemexpress LLC HYP51335MG
Synstatin (92-119) is an inhibitor of αvβ3/αvβ5 integrins and IGF1R, exhibiting anti-angiogenic, anti-proliferative, antioxidant, and anti-tumor activities. It competitively blocks the capture of αvβ3/αvβ5 integrins and IGF1R by syndecan-1, disrupting the formation of the syndecan-1: integrin: IGF1R ternary complex. It also inhibits integrin activation, talin-mediated signaling, and VEGF-induced angiogenesis, making it suitable for cancer and hepatocellular carcinoma research.
- Directly inhibits assembly of Sdc1:αvβ3 integrin:IGF1R ternary complex
- Binds to αvβ3 integrin, αvβ5 integrin, and IGF1R on activated vascular endothelial cells
- Inhibits αvβ3-dependent adhesion and migration of tumor cells
- Inhibits VEGF- and αvβ3-dependent angiogenesis
- Reduces hepatocellular carcinoma progression in thioacetamide-induced rats
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