Cayman Chemical SynthetIc HalIcIn 10mg

Supplier:  Cayman Chemical 3043610 MG

A JNK1 inhibitor (IC50 = 0.7 µM) with antidiabetic and antibiotic activity; selective for JNK1 over p38α, Furin, and lethal factor (IC50s = >100, >100, and >50 µM, respectively), as well as Akt at 100 µM; inhibits TNF-α-induced phosphorylation of c-Jun in a cell-based assay (EC50 = 6.23 µM); reduces blood glucose levels and restores insulin sensitivity in insulin insensitive mice at 25 mg/kg; active against carbapenem-resistant Enterobacteriaceae (MICs = 1-10 UG/ml), as well as multidrug-resistant A. baumannii and P. aeruginosa (MICs = 1-10 and 1-100 UG/ml, respectively); reduces the number of wound tissue CFUs in a mouse model of A. baumannii wound infection; reduces fecal bacterial load in a mouse model of C. difficile infection at 15 mg/kg

Catalog No. 50-299-2223