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Cayman Chemical SynthetIc -KavaIn 10mg
Supplier: Cayman Chemical 2652410 MG
A kavalactone with diverse biological activities; a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors (EC50s = 25 and 59 µM in the presence and absence of 300 µM (+)-kavain); reduces growth of WPMY-1 prostate cancer cells (IC50= 5.2 UG/ml); reduces LPS-induced TNF-α production in primary murine macrophages; reduces hind paw swelling and TNF-α production in a mouse model of collagen-induced arthritis; reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg)
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