Medchemexpress LLC T025 50mg | 2407433-00-3 | 99.6% | 382.42 | 50 MG

Supplier:  Medchemexpress LLC HY11229650MG

T025 is a highly potent, orally active inhibitor of Cdc2-like kinases (CLKs), demonstrating Kd values ranging from 0.074 nM to 32 nM across various CLK and DYRK isoforms (CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B, and DYRK2). This compound induces caspase-3/7-mediated cell apoptosis and reduces CLK-dependent phosphorylation. T025 exhibits anti-proliferative activities in both hematological and solid cancer cell lines, with IC50 values between 30-300 nM, making it effective for MYC-driven disease research.

• Orally active and highly potent inhibitor of Cdc2-like kinase (CLKs) and DYRKs.
• Induces caspase-3/7-mediated cell apoptosis.
• Reduces CLK-dependent phosphorylation.
• Exhibits anti-proliferative activities in hematological and solid cancer cell lines (IC50 values: 30-300 nM).
• Demonstrates anti-tumor efficiency, particularly for MYC-driven disease research.

Catalog No. 50-004-36726