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AdipoGen T0901317 (10 mg)
Supplier: AdipoGen AGCR12906M010
Chemical. CAS: 293754-55-9. Formula: C17H12F9NO3S. MW: 481.3. T0901317 is a potent, cell permeable and selective agonist of LXRalpha and LXRbeta. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol and regulation of HDL metabolism. T0901317 activates farnesoid X receptor (FXR) (EC50 ~5µM), less potent then LXR, but activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid. It also is a high-affinity ligand for the xenobiotic receptor pregnane X receptor (PXR). T0901317 binds and activates PXR with the same nanomolar potency with which it stimulates LXR activity. T0901317 shows anti-atherosclerosis, antidiabetic, insulin sensitizing, anticancer, anti-proliferative, metabolism modulating and neuroprotective properties.
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