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AdipoGen T0901317
SDP

Supplier:  AdipoGen AGCR12906M050

Encompass_Preferred

Chemical. CAS 293754-55-9. Formula C17H12F9NO3S. MW 481.3. T0901317 is a potent, cell permeable and selective agonist of LXRalpha and LXRbeta EC50 of 50nM, Kd values are 7 and 22 nM for LXR-alpha and LXR-beta, respectively, results in LXR-dependent up-regulation of ABC1 gene expression. The Liver X Receptors LXRalpha and LXRbeta are nuclear hormone receptors whose native ligands are oxysterols. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol and regulation of HDL metabolism. T0901317 activates farnesoid X receptor FXR EC50 ~5µM, less potent then LXR, but activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid. It also is a high-affinity ligand for the xenobiotic receptor pregnane X receptor PXR.

Catalog No. 50-256-2343


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