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Sigma Aldrich Fine Chemicals Biosciences T37i Mouse Brown Adipocyte
Supplier: Sigma Aldrich Fine Chemicals Biosciences SCC250
Brown adipose tissue (brown fat) has generated intense research interest due to its unique thermogenic properties and potential applications for development of treatments for metabolic diseases (1). Cellular models that reliably reflect the transition of preadipocytes to brown fat are necessary tools for investigating the mechanisms and roles of brown fat in metabolic systems.The T37i cell line is a rapidly proliferating brown preadipocyte cell line derived from a mouse hibernoma. Differentiation of T37i cells into brown adipocytes occurs when incubated with triiodothyronine (T3) and insulin over 3-6 days. Differentiation can also be induced by incubation with steroid hormones such as aldosterone which induces differentiation through its interaction with mineralocorticoid receptor (MR). Mature brown adipocytes are characterized via triglyceride accumulation morphology and expression of early adipogenic genes (2). Differentiated T37i cells express the thermogenic uncoupling protein 1
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