Tacrine hydrochloride

Description

A potent centrally acting anticholinesterase | CAS: 1684-40-8 | C13H15ClN2 | 234.73 g/mol

A potent centrally acting anticholinesterase for therapy of memory deficits in patients with Alzheimer's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in aqueous buffers

Notes
Refrigerate. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Specifications

• CAS: 1684-40-8
• Melting Point: 283°C to 284°C
• Color: Yellow
• Molecular Formula: C13H15ClN2
• Quantity: 5 g
• MDL Number: MFCD00150067
• UN Number: UN2811
• Merck Index: 14,9024
• Synonym: tacrine hydrochloride, 1,2,3,4-tetrahydroacridin-9-amine hydrochloride, tacrine hcl, hydroaminacrine, tenakrin, 9-amino-1,2,3,4-tetrahydroacridine hydrochloride, tacrine.hcl, unii-4966rng0bu, 1,2,3,4-tetrahydro-9-acridinamine hydrochloride, ccris 7250
• Solubility Information: Soluble in aqueous buffers
• InChI Key: ZUFVXZVXEJHHBN-UHFFFAOYSA-N
• SMILES: [H+].[Cl-].NC1=C2C=CC=CC2=NC2=C1CCCC2
• IUPAC Name: hydrogen 1,2,3,4-tetrahydroacridin-9-amine chloride
• Molecular Weight (g/mol): 234.73
• PubChem CID: 2723754
• Formula Weight: 234.73 (Anhydrous)
• Percent Purity: ≥98%
• Physical Form: Crystalline Solid
• Chemical Name or Material: Tacrine hydrochloride

Safety and Handling

Hazard Category	H302+H332-H315-H319-H335
Hazard Statement	GHS H Statement H331-H302-H315-H319-H335 Toxic if inhaled. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	216-867-5
RTECSNumber	AR9532500
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only