Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000063699

Apexbio Technology LLC Tacrolimus (FK506) 104987-11-3 200mg
SDP

Supplier:  Apexbio Technology LLC B2143200

Encompass_Preferred

Tacrolimus (FK506) is a macrolide immunosuppressant that acts as a potent inhibitor of calcineurin thereby selectively suppressing T-cell activation Mechanistically tacrolimus forms a complex with FKBP12 protein which binds to calcineurin and inhibits phosphatase activity subsequently blocking the transcription and secretion of cytokines notably interleukin-2 (IL-2) IL-3 IL-4 and interferon- Tacrolimus demonstrates an IC50 range between 0 1 1 nM in inhibiting IL-2 secretion in cellular assays Due to this mode of action it is commonly utilized in biomedical research focusing on T-cell response modulation cytokine-mediated signaling pathways transplantation immunology and autoimmune disease models both in vitro and in animal transplant studies

Catalog No. 50-000-63699


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.