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Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 200 MG
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Supplier:  Medchemexpress LLC HY13756A200MG

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Tacrolimus monohydrate is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex. This complex inhibits calcineurin phosphatase, which in turn inhibits T-lymphocyte signal transduction and IL-2 transcription. It exhibits immunosuppressive properties and is for research use only.

  • Binds to FK506 binding protein (FKBP) to form a complex
  • Inhibits calcineurin phosphatase
  • Inhibits T-lymphocyte signal transduction and IL-2 transcription
  • Exhibits immunosuppressive properties
  • Inhibits calcium-dependent events such as IL-2 gene transcription, NO synthase activation, cell degranulation, and apoptosis
  • Potentiates glucocorticoid and progesterone actions
  • May enhance TGFβ-1 gene expression
  • Inhibits T cell proliferation

Catalog No. 50-003-52012


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