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Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 500 MG
SDP

Supplier:  Medchemexpress LLC HY13756A500MG

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Tacrolimus monohydrate (FK506 monohydrate) is a macrocyclic lactone. It binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. It possesses immunosuppressive properties and is intended for research use only.

  • Inhibits calcium-dependent events like IL-2 gene transcription, NO synthase activation, cell degranulation, and apoptosis.
  • Potentiates actions of glucocorticoids and progesterone by binding to FKBPs.
  • May enhance expression of the TGFβ-1 gene.
  • Inhibits T cell proliferation in response to T cell receptor ligation.

Catalog No. 50-003-51044


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