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Apexbio Technology LLC Tadalafil 171596-29-5 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A43275.1

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Tadalafil (CAS 171596-29-5) also known as IC351 is a selective inhibitor of phosphodiesterase type 5 (PDE5) a primary phosphodiesterase isoenzyme responsible for hydrolyzing cyclic guanosine monophosphate (cGMP) in pulmonary vasculature By competitively and reversibly inhibiting PDE5 tadalafil elevates intracellular cGMP levels thereby inducing vasodilation and attenuating pathological pulmonary arterial constriction Due to high selectivity tadalafil shows minimal inhibition of other PDE isoforms such as PDE1 PDE4 PDE6 PDE7 PDE8 PDE9 and PDE10 It is commonly studied in pulmonary arterial hypertension research and utilized clinically for erectile dysfunction

Catalog No. 50-000-61962


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