ABclonal Technology TAF1 Rabbit pAb

Supplier:  ABclonal Technology A157301000UL

This gene encodes the largest subunit of TFIID, a basal transcription factor required for RNA polymerase II activity. TFIID binds to the core promoter to position the polymerase and assembles the transcription complex. It also serves as a channel for regulatory signals and interacts with activators and other regulators to influence transcription initiation. This subunit contains two protein kinase domains and has acetyltransferase activity, acting as a ubiquitin-activating/conjugating enzyme. Mutations in this gene cause Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing results in multiple transcript variants, some sharing exons with TAF1 and additional downstream DYT3 exons.

Catalog No. 50-001-07920