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Selleck Chemical LLC TAK-243 (MLN7243) 2mg 1450833-55-2
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Supplier:  Selleck Chemical LLC S83412MG

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TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ¿ 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. TAK-243 (MLN7243) induces ER stress, abrogates NF?B pathway activation and promotes apoptosis. *For Research & Development use only.  Product is not intended for drug, household, or human consumption.

Catalog No. 50-194-8193


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