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Medchemexpress LLC TAK-285 | 871026-44-7 | C26H25ClF3N5O3 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY15196100MG

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TAK-285 is a potent, selective, ATP-competitive, and orally active HER2 and EGFR (HER1) inhibitor. It demonstrates effective antitumor activity and can cross the blood-brain barrier (BBB). This compound exhibits significant growth inhibitory activity against BT-474 cells.

  • Potent and selective HER2 and EGFR (HER1) inhibitor
  • IC50 values of 17 nM for HER2 and 23 nM for EGFR (HER1)
  • Shows over 10-fold selectivity for HER1/2 compared to HER4
  • Less potent against MEK1/5, c-Met, Aurora B, Lck, and CSK
  • Demonstrates effective antitumor activity
  • Can cross the blood-brain barrier (BBB)
  • Exhibits significant growth inhibitory activity against BT-474 cells with a GI50 of 17 nM
  • Inhibits MEK1, MEK5, c-Met, Aurora B, Lck, CSK, and Lyn B with varying IC50s

Catalog No. 50-003-72711


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