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Medchemexpress LLC TAK-285 | HER2/EGFR inhibitor | 871026-44-7 | C26H25ClF3N5O3 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1519610MM/1ML

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TAK-285 is a potent, selective, ATP-competitive, and orally active inhibitor of HER2 and EGFR (HER1), with IC50 values of 17 nM and 23 nM, respectively. It exhibits more than 10-fold selectivity for HER1/2 over HER4 and is less potent against MEK1/5, c-Met, Aurora B, Lck, and CSK. This compound demonstrates effective antitumor activity and can cross the blood-brain barrier (BBB).

  • Potent, selective, ATP-competitive, and orally active HER2 and EGFR (HER1) inhibitor
  • IC50 values: HER2: 17 nM; EGFR: 23 nM
  • Exhibits more than 10-fold selectivity for HER1/2 over HER4
  • Less potent against MEK1/5, c-Met, Aurora B, Lck, and CSK
  • Demonstrates effective antitumor activity
  • Can cross the blood-brain barrier (BBB)

Catalog No. 50-003-74136


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